FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination

摘要

The degradation of the ubiquitin-like protein FAT10 requires ubiquitination: degradation was inhibited in cells expressing a nonpolymerizable ubiquitin mutant or harboring a thermolabile ubiquitin-activating enzyme. Degradation of FAT10 is accelerated after induction of apoptosis, suggesting that it plays a role in prosurvival pathways.